Kidney Injury Molecule-1 (Kim-1) Sebagai Biomarker Dini Nefropati Diabetik Pada Pasien Diabetes Melitus Tipe 2



KIM-1, Diabetic nephropathy, Albuminuria


Diabetic nephropathy is a chronic complication of type 2 diabetes mellitus (DM). To prevent the onset or progression of nephropathy, a biomarker is needed that can detect kidney problems at an early stage. This study aims to determine differences in urine KIM-1 levels and correlation of levels of KIM-1 with albuminuria in patients with Non-Nephropathy DM, Insipien Nephropathy and Diabetic Nephropathy and the role of KIM-1 as an early biomarker of Diabetic Nephropathy. This research was conducted at Dr. Wahidin Sudirohusodo and his networking hospital. This study used a cross-sectional design with the number of type 2 DM patients as many as 78 people who met the inclusion criteria. The results showed that KIM-1 levels in patients with Non-Nephropathy DM (albuminuria [uALB] <20 mg/L), Ineffective Nephropathy (uALB 20-300 mg / L) and Diabetic Nephropathy (uALB> 300 mg/L) respectively is 0.862 ± 0.246 ng / mL, 2.409 ± 0.816 ng/mL and 3.503 ± 0.370 ng / mL. There were differences in mean KIM-1 levels between Non Nephropathy and Nephropathy Insipid (sig = 0.000 p <0.05), Non Nephropathy and Diabetic Nephropathy (sig = 0.000 p <0.05), Insipid Nephropathy and Diabetic Nephropathy (sig = 0.000 p <0.05) Correlation between KIM-1 level with albuminuria concentration in patients with Non Nephropathy DM (r = 0.948; sig <0.05), Nephropathy Insipien (r = 0.969; sig <0.05) and Diabetic Nephropathy (r = 0.911; sig <0.05). There are levels of KIM-1 that exceed the normal limit (> 0.837 ng / mL) in patients with non-nephropathy DM (normoalbuminuria) so that KIM-1 can be considered as an early biomarker of diabetic nephropathy.


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Ahmed SA. & Hamed MA. (2015). Kidney Injury Molecule-1 as a predicting factor for inflamed kidney, diabetic and diabetic nephropathy in egypthian patients. Diabetes Care

Alter Ml. et al. (2010). Early Urinary and Plasma Biomarkers for Experimental Diabetic Nephropathy. Clin. Lab. 58:659-671

American Diabetes Association (ADA). (2010). Standart of Medical Care in Diabetes. Diabetes Care Journals.

Bangstad HJ., Seljeflot I., Berg TJ., & Haussen KF. (2009). Tubulointersitial expansion is associated endhotelial dysfunction and infalammation in Type 1 Diabetes. Scand J Clin Lab Invest 69:138-49

Barratt J. & Topham P. (2007). Urine proteomics: the present and future of measuring urinary protein components in disease. CMAJ 177:361-8

Bonventre JV. (2009). Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more. Nephrol Dial Transplant.

Borst MHd. et al. (2007). Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin- angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol.

Carlsson AC. et al. (2014). Kidney injury molecule (KIM)-1 is associated with insulin resistance: Results from two community-based studies of elderly individuals. Diab Resh Clin Pract.

Chaudhary K. et al. (2010). The emerging role of biomarkers in diabetic and hypertensive chronic kidney disease. Curr Diabetes Rep.

Dabla PK. (2010). Renal function in diabetic nephropathy. World J Diabetes

Dinas Kesehatan Kota Makassar. (2012). Laporan Tahunan Dinas Kesehatan Kota Makassar Tahun 2012. Makassar: Dinkes Kota Makassar

Dinas Kesehatan Provinsi Sulawesi Selatan. (2012). Prevalensi Penderita Diabetes Mellitus Kota Makassar. Makassar: Dinkes Prov Sulsel.

Han WK. et al. (2002). Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int.

Ichimura T., Hung CC., Yang SA., Stevens JL., & Bonventre JV. (2004). Kidney Injury Molecule-1: A Tissue and Urinary Biomarker for Nephrotoxicant-Induced Renal Injury. Am J Physiol Renal Physiol.

Ichimura T. et al. (2008). Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest.

International Diabetes Federation (IDF). (2014). Complications of Diabetes. Akses:

Narita T., Hosoba M., Kakei M., & Ito S. (2006). Increased urinary biomarker of immunoglobulin G, ceruloplastin, and transferrin predict development of microalbuminuria in patients with type 2 diabetes mellitus. Diabetes care 29:142-4

Nauta FL. et al. (2011). Glomerular and tubular damage markers are elevated in patients with diabetes. Diabetes Care. 34:975–81.

Nielsen SE. et al. (2012). Tubular Markers Are Associated with Decline in Kidney function in Proteinuric type 2 Diabetic patients. Diabetic Reseacrh and Clinical Practice.

Obineche EN. & Adem A. (2005). Update in Diabetic Nephropathy. Int J Diabetes & Metabolism (2005) 13: 1-9

Pacific Biomarkers. (2013). Novel Biomarkers of Diabetic Nephropathy. Pacific Biomarker Press Release

Parving H. et al. (2004). Diabetic Nephropathy, chap. 38, in Brenner and Rector's the Kidney, 7th ed., edited by Brenner BM, Philadelphia, WB Saunders, pp 1777-1818.

Philips AO. & Steadman R. (2002). Diabetic Nephropathy: the central role of renal tubulus proximal cells in tubulointersitial injury. Histo Histopathol 17:247-52

Retnakaran R., Cull CA., thorne KI., Adler AI., & Holman R. (2006). Risk factor of renal dysfuction in type 2 diabetes: UK prospective diabetes study 74. Diabetes 55:1832-9

Rossing K. (2007). Progression and remission of nephropathy in type 2 diabetes: new strategies of treatment and monitoring. Dan Med Bull.

Sang Soo K. et al. (2012). Clinical implication of urinary tubular markers in early stage of nephropathy with type 2 diabetes patients. Diabetes research and Clinical Practice 97 251-257

Tecke BK., Tecke H., Aktas G., & Sit M. (2014). Evaluation of the kidney injury molecule (KIM--1) levels in patients with nephropathy diabetic. Clin Invest Med Vo. 37 No. 6

Timmeren MMv. et al. (2006). Tubular Kidney Injury Molecule-1 In Protein Overload Nephropathy. Am J Physiol Renal Physiol.

Vaidya VS. et al. (2007). Urinary kidney injury molecule-1: a sensitive quantitative biomarker or early detection of kidney tubular injury. Am J Physiol Renal Physiol.

Vora J. (2004). Diabetic Nephropathy: Detection and Treatment of RenalDisease In Patients with Diabetes. Proceeding presented on 12th International Congress of Endocrinology Vol. 4

Vujicic B. et al. (2012). Diabetic Nephropathy. Intech Open Acess.

Wolkow PP., Niewczas MA., & Perkins B. (2008). Association of urinary inflammatory and renal decline in microalbuminuric type 1 diabetics. J Am Soc Nephrol 19:789-97

World Health Organization (WHO). (2014). Definition and Diagnosis of Diabetes Mellitus. Akses:

Zelmanovitz T. et al. (2009). Diabetic nephropathy. Diabetology and Metabolic Syndrome.

Zhang Z., Humpreys BD., & Bonventre JV. (2007). Shedding of urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinase and Juxtamembrane region. J Am Soc Nephrol 18: 2704–2714




How to Cite

Tangkelangi, M. (2017). Kidney Injury Molecule-1 (Kim-1) Sebagai Biomarker Dini Nefropati Diabetik Pada Pasien Diabetes Melitus Tipe 2. JURNAL INFO KESEHATAN, 15(2), 367–379. Retrieved from



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